pentobarbital will minimize the level or result of ethotoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Monitor.
pentobarbital will minimize the extent or outcome of bexarotene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may raise the metabolism of ifosfamide to its Lively alkylating metabolites.
Remark: Barbiturates could increase adverse effects, which include respiratory melancholy, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
pentobarbital will lessen the extent or effect of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.
pentobarbital will decrease the level or influence of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to some lessen in fentanyl plasma concentrations, insufficient efficacy or, maybe, enhancement of the withdrawal syndrome within a client who may have developed Bodily dependence to fentanyl.
CYP3A4 inducers might raise the development in the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Intently check clients having ifosfamide with CYP3A4 inducers for toxicities and contemplate dose adjustment.
pentobarbital will enhance the stage or impact of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lower the level or influence of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. If unable to avoid coadministration of stiripentol with potent CYP3A4 inducers, maximize stiripentol dose.
pentobarbital will lower the level or influence of celecoxib by affecting hepatic enzyme CYP2C9/ten metabolism. Minimal/Importance Unidentified.
Keep track of Carefully (one)pentobarbital will minimize the level or impact of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Right after stopping a CYP3A4 inducer, since the effects in the inducer decline, the fentanyl plasma concentration will increase which could increase or extend the two the therapeutic and adverse effects.
Coadministration of zuranolone with other CNS depressants check here might raise impairment of psychomotor efficiency or CNS depressant effects. If unavoidable, take into consideration dose reduction. .
pentobarbital will minimize the level or impact of fostemsavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.